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pentobarbital decreases amounts of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers can lessen panobinostat ranges by ~70% and produce treatment method failure.pentobarbital will minimize the extent or impact of osilodrostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism.Watc